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cheap generic cialis It may still be important to measure rare variants if their effects are devastating and essentially avoidable such as TPMT variants in 6 mercaptopurine dosing Wang and Weinshilboum, 2006 or phenylalanine hydroxylase deficiency in phenylketonuria Scriver, 2007, but even there information on prevalence is useful in estimating the costs of screening or the magnitude of the population likely to need intervention, if interventions are available